The Ottomans extended their power in maritime too and they captured most of the Mediterranean islands. The island of Sakiz was under the domination of the Geneoise State and they were paying taxes to the Ottoman Empire, besides, their trading was controlling by the Ottomans. The island was one of the important trade centres of the Aegean Sea. The countries without capitulation were bringing their goods to Sakiz and by the Venetian, Genoise and Dubrovic merchants they were selling those goods to the Ottomans.

The Geneoise islanders were not paying their taxes regularly, moreover, they were attacking the Ottoman forces. Under these circumstances, a navy was sent to the island commanded by Piyale Pasha and Sakiz was captured. His victory brought Piyale Pasha the vizier rank, in 1568.