The Ottoman-Saffavid conflict was continuing since the Mehmet the Conqueror’s period. Selim’s Iran campaign increased these conflicts and Saffavid’s allied with the Mamelukes of Egypt. On hearing this allience Selim campaigned to Egypt (June 5, 1516). On the 27th day of August the Ottoman Army arrived the Mameluke borders. On the 18th August the Castle of Antep had surrendered and the Castle of Besni followed it the other day.

The battle had began on 24th August 1516 in Mercidabik. The Mameluke Army fell in defending their lands against the powerful Ottoman artillery. They have surendered. The Mameluke Sultan Gansu Gavri was found dead. With this victory, a passage through Syria was opened to the Ottomans.