He was one of the grandchildren of Mevlana (the founder of the Mevlevi sect). He became vizier in 1458, grand vizier in 1478. He assisted Sultan Mehmed II, while he was preparing his Code of Laws. Karamani Mehmed Pasha wrote prose and verse by using “Nisani” pen name. His most famous work is History of Ottoman Sultans. He supported Cem Sultan in his throne struggle following the death of Mehmed The Conqueror. He was killed by the supporters of Sultan Bayezid II. His tomb is in the courtyard of Karamani Mehmed Pasha Mosque in Kumkapi.

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